         |
| Goal |
To
carry out state-of-the-art research on the prevention and treatment of HIV
infection to promote medical readiness in U.S. military forces. |
| Objective
|
- Support
the development of a safe and effective HIV vaccine.
- Support
the development of new biochemical and genetic strategies to slow HIV
disease progression
- Support
natural history studies for the purpose of evaluating the efficacy of
intervention strategies.
|
|
Action
Steps
|
- Define
the global molecular epidemiology of HIV to assist with candidate vaccine
selection.
- Explore
novel vaccine technologies.
- Conduct
vaccine trials in endemic areas.
- Assess
the immune response and efficacy of vaccine candidates.
- Evaluate
potential therapies for treatment of HIV infection and potential for
immune reconstitution.
- Evaluate
prevalence of drug resistance, develop rapid genetic assay for resistant
mutants, and methods for genetic targeting of novel therapies in vivo.
- Participate
in national surveillance of AZT resistance.
- Develop
a comprehensive panel of immunologic, virologic, and functional parameters
for management of HIV infection.
- Support
natural history studies and specimen repositories.
|
|
Descriptions
|
Vaccine,
therapeutic, and epidemiological research, including vaccine design, development
and testing in the U.S. and overseas locations; epidemiologic studies
of vaccine field studies; and conclusion of drug treatment and behavior
studies.
|
|
Resources
|
FY95
|
FY96
|
FY96
|
|
$
38.5 million
|
$
27.7 million
|
$
24.0 million
|
|
Populations
Served
|
Active
duty personnel.
|
|
Constituency
Involvement
|
Clinicians,
researchers, and active duty personnel.
|
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